Journal of the Practice of Cardiovascular Sciences

REVIEW ARTICLE
Year
: 2022  |  Volume : 8  |  Issue : 1  |  Page : 9--16

Genetic targets in the management of atrial fibrillation in patients with cardiomyopathy


Michaela Zigova1, Eva Petrejčíková1, Marta Mydlárová Blaščáková1, Ján Kmec2, Jarmila Bernasovská1, Iveta Boroňová1, Martin Kmec2 
1 Department of Biology, Faculty of Humanities and Natural Sciences, University of Prešov, Prešov, Slovakia
2 Cardiocentre of Faculty Hospital J. A. Reiman in Prešov, Prešov, Slovakia

Correspondence Address:
Michaela Zigova
Department of Biology, Faculty of Humanities and Natural Sciences, University of Prešov, Prešov
Slovakia

Cardiomyopathies are heterogeneous health conditions with the potential for atrial fibrillation. The management of patients with cardiomyopathy accompanied by atrial fibrillation is complicated by the maintenance of sinus rhythm, toxicity, or other complications. There is a lack of information about the reasons for therapy response heterogeneity or therapy failure. Our searching strategy of scientific databases declares a potentially important role of genetics in patients' management. The promising target could be the 4q25 locus and its sequence variants. Molecular-genetic analyses may shed new light on anti-atrial fibrillation therapy in cardiomyopathy patients and help reveal the genetic subtypes of cardiomyopathy patients. In this sense, the purpose of our study is to examine the evidence for genetic variation influencing the efficacy of pharmacological or invasive therapies for atrial fibrillation, especially at the 4q25 locus, in cardiomyopathy patients and declare the importance of detected genetic markers responsible for positive or negative responses to specific anti-atrial fibrillation therapies.


How to cite this article:
Zigova M, Petrejčíková E, Blaščáková MM, Kmec J, Bernasovská J, Boroňová I, Kmec M. Genetic targets in the management of atrial fibrillation in patients with cardiomyopathy.J Pract Cardiovasc Sci 2022;8:9-16


How to cite this URL:
Zigova M, Petrejčíková E, Blaščáková MM, Kmec J, Bernasovská J, Boroňová I, Kmec M. Genetic targets in the management of atrial fibrillation in patients with cardiomyopathy. J Pract Cardiovasc Sci [serial online] 2022 [cited 2022 Jun 24 ];8:9-16
Available from: https://www.j-pcs.org/article.asp?issn=2395-5414;year=2022;volume=8;issue=1;spage=9;epage=16;aulast=Zigova;type=0