Journal of the Practice of Cardiovascular Sciences

: 2016  |  Volume : 2  |  Issue : 3  |  Page : 157--162

Metabolic management of heart disease

Akshyaya K Pradhan 
 Department of Cardiology, King George Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Akshyaya K Pradhan
Department of Cardiology, King George Medical University, Lucknow, Uttar Pradesh

Alterations of cardiac metabolism occur with ischemia and heart failure (HF). This results in increased utilization of noncarbohydrate substrates for energy production and depletion of myocardial adenosine triphosphate, phosphocreatine, and creatine kinase with decreased efficiency of mechanical work. A direct approach to manipulate cardiac energy metabolism consists in modifying substrate utilization by the failing heart. The results of research suggest that shifting the energy substrate preference away from fatty acid metabolism and toward glucose metabolism could be an effective adjunctive treatment in patients with HF, in terms of left ventricular function and glucose metabolism improvement. In this paper, some of these concepts will be discussed, and the role of drugs such as trimetazidine will be discussed.

How to cite this article:
Pradhan AK. Metabolic management of heart disease.J Pract Cardiovasc Sci 2016;2:157-162

How to cite this URL:
Pradhan AK. Metabolic management of heart disease. J Pract Cardiovasc Sci [serial online] 2016 [cited 2023 Feb 7 ];2:157-162
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