Journal of the Practice of Cardiovascular Sciences

REVIEW ARTICLE
Year
: 2016  |  Volume : 2  |  Issue : 3  |  Page : 151--156

Mendelian randomization: A biologist's perspective


Subhoshree Ghose, Akash Kumar Bhaskar, Anju Sharma, Shantanu Sengupta 
 Proteomics Lab, Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India

Correspondence Address:
Subhoshree Ghose
Proteomics Lab, IGIB, Mathura Road, New Delhi
India

Mendelian randomization (MR) is a statistical technique used by genetic epidemiologists to determine causal effects, i.e. whether a biomarker actually influences disease risk, is it just a statistical association. It uses common genetic polymorphisms with known biological effects (propensity to drink alcohol) or effects that mimic modifiable exposures (raised blood cholesterol). For MR, it is necessary that the genotype only affects the disease status indirectly through its effect on the exposure of interest.


How to cite this article:
Ghose S, Bhaskar AK, Sharma A, Sengupta S. Mendelian randomization: A biologist's perspective.J Pract Cardiovasc Sci 2016;2:151-156


How to cite this URL:
Ghose S, Bhaskar AK, Sharma A, Sengupta S. Mendelian randomization: A biologist's perspective. J Pract Cardiovasc Sci [serial online] 2016 [cited 2022 Oct 3 ];2:151-156
Available from: https://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=3;spage=151;epage=156;aulast=Ghose;type=0