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Year : 2019  |  Volume : 5  |  Issue : 2  |  Page : 68-75

G protein-coupled receptor signaling in cardiovascular system: Specificity versus diversity

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

Correspondence Address:
Prof. Shyamal K Goswami
School of Life Sciences, Jawaharlal Nehru University, New Delhi - 110 067
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpcs.jpcs_37_19

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In metazoan organisms, communication of the constituent cells to its exterior is an essential component of tissue homeostasis and organ function. A plethora of growth factors, cytokines, hormones, regulatory small molecules, etc., interact with the cells surface receptors to initiate the signaling process that is transduced to the cell interior, regulating its functions. Over the years, thousands of such receptors have been identified and characterized. This number has substantially gone up in the postgenome era. Although the mechanisms of signal transduction by cell surface receptors is of immense interest for both clinicians and basic biologists, certain group of receptors have drawn equal attention of both the communities. One such group is the G protein-coupled receptors (GPCRs). Over the past half a century, this group of receptors has been extensively investigated, and a volume of information regarding their complexity as well as diversities has been revealed. Another interesting aspect of the GPCR study is their predominant roles in drug discovery and development. A substantial number of commonly used drugs are targeted toward the GPCR family, and several more are expected to be coming to the market in near future. Taking into consideration of the importance of these receptors, the following review summarizes certain fundamental aspects of its signaling mechanisms. Considering the vast information available on GPCRs and their importance in human health and diseases, following review provides a broad outline on the mechanisms of their functional diversity.

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