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Year : 2016  |  Volume : 2  |  Issue : 3  |  Page : 151-156

Mendelian randomization: A biologist's perspective

Proteomics Lab, Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India

Correspondence Address:
Subhoshree Ghose
Proteomics Lab, IGIB, Mathura Road, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpcs.jpcs_62_16

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Mendelian randomization (MR) is a statistical technique used by genetic epidemiologists to determine causal effects, i.e. whether a biomarker actually influences disease risk, is it just a statistical association. It uses common genetic polymorphisms with known biological effects (propensity to drink alcohol) or effects that mimic modifiable exposures (raised blood cholesterol). For MR, it is necessary that the genotype only affects the disease status indirectly through its effect on the exposure of interest.

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